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How to prevent microvascular complications of diabetes

Looking for type 2 diabetes complications? Search now! Find updated content daily for type 2 diabetes complications Discover Best Foods to Treat Type 2 Diabetes Quickly & Lower Blood Sugar Naturally At Home. We Are Committed To Help You Get The Best Out Of Your Type 2 Diabetes Right Now - Get Now Microvascular complications (retinopathy, nephropathy, and neuropathy) affect hundreds of millions of patients with type 2 diabetes. They usually affect people with longstanding or uncontrolled disease, but they can also be present at diagnosis or in those yet to have a diagnosis made

Retinopathy, nephropathy and neuropathy are microvascular complications and macrovascular complication affects heart, brain and foot. In preventing retinopathy, glycaemic and blood pressure control is essential. Laser photocoagulation therapy can prevent loss of vision in non-proliferative or proliferative diabetes mellitus Detecting and treating complications of diabetes are major components for these interventions. 3 4 5 Strong evidence supports the need to achieve and maintain proper glycemic control to prevent the incidence (primary prevention) or progression (secondary prevention) of microvascular complications It has been suggested the renin-angiotensin-aldosterone system (RAAS) blockade, a common blood pressure lowering option, may also be effective in the management of microvascular complications in diabetic patients

Type 2 Diabetes Complications - Results Updated Toda

  1. The management of type 1 and 2 diabetes mellitus (DM) requires addressing multiple goals, with the primary goal being glycemic control. Maintaining glycemic control in patients with diabetes prevents many of the microvascular and macrovascular complications associated with diabetes
  2. In light of the above strong evidence linking diabetes and CVD and to control and prevent the microvascular complications of diabetes, the ADA has issued practice recommendations regarding the prevention and management of diabetes complications. Blood pressure should be measured routinely. Goal blood pressure is < 130/80 mmHg
  3. This CPD module provides an update on the microvascular complications of diabetes — nephropathy, retinopathy, and peripheral and autonomic neuropathies — and their prevention. It includes information on how these problems arise, risk factors for their development, and how they are monitored and managed
  4. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective.
  5. antly in tissues where.
  6. Most complications can be prevented or delayed with targeted glucose control; every percentage point drop in HbA1c results in a 35% risk reduction of microvascular complications. Diabetic retinopathy is the most frequent cause of new-onset blindness in adults between 20-74 years of age
  7. In order to effectively monitor for vascular complications make sure you: Keep up on your regular and routine doctor visits Get your A1c checked two to four times per year Get an annual eye exa

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  1. 1. To recognize macrovascular complications as the leading cause of death in people with diabetes 2. To be familiar with risk factors for macrovascular complications of diabetes 3. To understand the impact of multifactorial risk reduction on outcomes in patients with diabetes Objective
  2. tions of diabetes, is prevention. Like other microvascular complications of diabetes, there are strong associa-tions between glucose control (as measured by A1C) and the risk of developing diabetic nephropathy. Patients should be treated to the lowest safe glucose level that can be obtained to prevent or control diabetic nephropathy. 9,11,12.
  3. There has been a growing interest in blocking the renin-angiotensin system as a means to prevent microvascular complications of diabetes, 60 and in adults, reduction of BP has been shown to be an important option to prevent the progression of nephropathy and retinopathy
  4. Utilize strategies to reduce the development and progression of diabetes-related complications. Implement practical strategies to detect, prevent and manage common acute diabetes-related complications such as hyper- and hypoglycemia. Establish effective techniques to educate diabetes patients on potential complications and management options
  5. Check Your ABCs Knowing your blood glucose, blood pressure, and cholesterol levels can be an effective way to prevent complications of diabetes that are related to your heart, eyes, nerves, and kidneys. Your hemoglobin A1C (a three-month average of blood sugar), blood pressure, and cholesterol are important numbers that you should understand
  6. The longer you have diabetes — and the less controlled your blood sugar — the higher the risk of complications. Long-term complications of diabetes develop gradually. Eventually, they may be disabling or even life-threatening. Overall, diabetes complications can be studied into 2 majors i.e. Microvascular and Macrovascular
  7. Preventing macrovascular complications. Finding strategies to reduce the development of macrovascular complications has been challenging. The United Kingdom Prospective Diabetes Study (UKPDS), to date the largest and longest prospective randomised trial in people with type 2 diabetes, showed that intensive blood glucose control alone failed to reduce macrovascular complications significantly,5.

Diabetes and related complications are associated with long-term damage and failure of various organ systems. The line of demarcation between the pathogenic mechanisms of microvascular and macrovascular complications of diabetes and differing responses to therapeutic interventions is blurred How to prevent complications of diabetes. The old saying an ounce of prevention is worth a pound of cure definitely holds true when speaking about diabetes. The truth is, diabetes complications are often incurable, and the management involves slowing the rate of disease progression. Preventing these complications in the first place is the. Microvascular complications (retinopathy, nephropathy, and neuropathy) affect hundreds of millions of patients with type 2 diabetes. They usually affect people with longstanding or uncontrolled disease, but they can also be present at diagnosis or in those yet to have a diagnosis made. The presentation and progression of these complications can lead to loss of visual, renal, and neurologic. Microvascular complications: Diabetes-related eye disease. Microvascular complications: Diabetes-related neuropathy. Microvascular complications: Foot care. Microvascular complications: Nephropathy. Managing glycaemic emergencies. Mental health and type 2 diabetes. Managing multimorbidity in people with type 2 diabetes This new live-virtual continuing education course provides a state-of-the-art update on managing and preventing diabetes-related complications to the spectrum of health care providers. Learning activities will center on strategies to prevent and treat microvascular complications including retinopathy, nephropathy, and neuropathy as well as.

How To Reverse Type 2 Diabetes - Treat Type 2 Diabete Naturall

  1. Hypoglycaemia and ketoacidosis. Name 3 microvascular and 3 macrovascular complications of T1DM. Microvascular: retinopathy. nephropathy. neuropathy. Macrovascular: Ischaemic heart disease. Peripheral vascular disease. Cerebrovascular vascular disease
  2. Uncontrolled diabetes can lead to a host of short- and long-term pathophysiological effects, including microvascular complications (neuropathy, retinopathy, and diabetic kidney disease), cardiovascular damage, gastrointestinal complications, increased risk of infection, and depression. 1 Since diabetes complications can significantly impact a.
  3. Free UK Delivery on Eligible Order
  4. on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015; 3: 866-75 pmid:26377054 . View Articl
  5. The long-term issues resulting from diabetes are not type-specific, although some are more prevalent in type 1 diabetes, while type 2 disease appears to increase the risk of certain complications. This module aims to help pharmacists understand the main microvascular complications of diabetes, so they can play a part in preventing and detecting.
  6. In light of the above strong evidence linking diabetes and CVD and to control and prevent the microvascular complications of diabetes, the ADA has issued practice recommendations regarding the prevention and management of diabetes complications. Blood pressure should be measured routinely. The goal blood pressure is < 130/80 mmHg
  7. in prediabetes was inconclusive in the DPP [21]. Recently, the Carmelina study has shown.

How to prevent the microvascular complications of type 2

  1. Diabetes Self-Management Education and Support in Type 2 Diabetes. A Joint Position Statement of Diabetes Educators, and the Academy of Nutrition and Dietetics. The Diabetes Educator OnlineFirst. June 5,2015. 4. American Diabetes Association. Microvascular complications and foot care. Sec. 9. In Standards of Medical Care in Diabetes—2015.
  2. Certainly, managing glucose is critical to prevent microvascular complications, in particular. There is strong epidemiologic data that adverse cardiovascular outcomes are greater in people with higher levels of hemoglobin A1C, but the evidence is less striking for improving cardiovascular outcomes from glucose control alone
  3. There is a lot that can be done to prevent problems. Diabetes affects blood vessels. The complications that happen because of harm to the blood vessels can be divided into effects on large blood vessels (macrovascular), and complications from harm to small blood vessels (microvascular)

However, in addition to preventing macrovascular diseases, statins may also be able to retard the progression of microvascular complications of diabetes. Indeed, in addition to reducing lipid levels, these agents can improve endothelial function and reduce oxidative stress, which can improve microvascular function OBJECTIVE We examined whether the presence of microvascular complications was associated with increased subsequent risk of cardiovascular disease (CVD) among participants with type 1 diabetes in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study followed for >35 years To prevent microvascular complications of diabetes, the goal for glycemic control should be as low as is feasible without undue risk for adverse events or an unacceptable burden on patients. Treatment goals should be based on a discussion of the benefits and harms of specific levels of glycemic control with the patient [8]

Prevention of microvascular and macrovascular

  1. Early prevention of diabetes microvascular complications in people with hyperglycaemia in Europe. ePREDICE randomized trial. Study protocol, recruitment and selected baseline data. PLoS One. 2020 Apr 13;15(4):e0231196. doi: 10.1371/journal.pone.0231196. eCollection 2020
  2. Numerous complications affecting various organ systems can develop as a result of diabetes out of control. These complications can be divided into 2 major categories: microvascular and macrovascular. Microvascular complications affect smaller blood vessels and can lead to damage in the kidneys (nephropathy
  3. It is known that prolonged high blood glucose levels can create a pro-inflammatory environment that can promote the development of microvascular complications, such as retinopathy, neuropathy, and kidney disease. Similarly, the development of macrovascular complications (i.e., cardiovascular disease) is more likely for those with diabetes
  4. Complications Diabetes complications can be categorised into those caused by damage to the microvascular system supplying nerves and organs, and those caused by macrovascular damage. Some complications involve both micro and macrovascular damage, as seen in diabetic foot problems

Globally, diabetes‐related complications pose a major challenge to healthcare workers and a huge socioeconomic burden to society. Although, macrovascular complications, notably coronary heart diseases and ischemic stroke, are the leading causes of death in diabetic patients in the West, diabetic microvascular complications, including nephropathy, retinopathy and neuropathy, cause substantial. Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies. 2Department of Medicine, Nephrology Division, Federal University of São Paulo, SP, Brazil. 3Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA. 4Department of Molecular and Cellular Pharmacology. Prevention and Management of Diabetes Complications is four-day livestream course developed for clinicians who want to design comprehensive diabetes-related complications prevention and treatment strategies based on the latest scientific information in the field in ways that are feasible in their busy clinical practices You can take many steps to prevent any of these complications from occurring or becoming worse. Diabetes is a vascular disease and complications in type 2 diabetes can be described as microvascular (small blood vessels) or macrovascular (large blood vessels) complications (Microvascular and Macrovascular Complications of Diabetes) Type 2 diabetes (T2D) is a growing health threat in both developed and developing countries [].Hyperglycemia and the broad spectrum of additional risk factors contribute to the development of both macrovascular (e.g., cardiovascular, cerebrovascular, and peripheral vascular diseases) and microvascular (nephropathy, retinopathy, and neuropathy) complications []

Ticagrelor and the Prevention of Microvascular Complications in Diabetes Patients with Lower Extremity Arterial Disease; Rationale and Design of the Hema-Kinesis Trial. Rosenson RS, Chen Q, Najera SD, Lee ML, Cho DJ. Cardiovasc Drugs Ther 2018 Oct;32 (5):443-451. doi: 10.1007/s10557-018-6815-9. PMID: 30074112 There are two main types of complications of diabetes, which are called microvascular and macrovascular. Macrovascular, referring to the term macro, involves issues with macro circulation, which is the circulatory system itself, in other words causing disease in the cardiovascular system itself, while the micro kind involves micro circulation, involving things such as the eyes, the kidneys.

Preventing Microvascular Complications of Diabete

Diabetes Mellitus: Management of Microvascular and

Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study. Diabetes Res Clin Pract 1995; 28: 103-17 Microvascular complications are diabetes-specific, whereas macrovascular complications are similar to those in nondiabetics but occur at greater frequency in individuals with diabetes. Nonvascular complications include gastroparesis, infections, skin changes, and hearing loss Diabetes Complications. minus. Related Pages. Diabetes complications can develop without any obvious symptoms. But don't let out of sight mean out of mind. You can take action to lower your risk for complications and reduce their impact on your life Microvascular complications from T2DM are common and evidence shows that early detection and identification of risk factors for retinopathy, nephropathy, and neuropathy may delay or prevent the progression towards blindness, end-stage renal disease, and diabetic foot ulcers, respectively

Diabetic retinopathy and diabetic foot ulcer are the most frequent, but also the most disabling complications of diabetes mellitus, with a sinister impact on patients' quality of life. Microvascular changes related to the deleterious effect of chronic hyperglycemia play an important role in the pathophysiology of both clinical entities by multiple molecular pathways Possible complications of type 2 diabetes include: Macrovascular. Atherosclerotic cardiovascular disease (CVD) CVD including stroke and peripheral arterial disease is the leading cause of death in people with type 2 diabetes [Davies, 2018].People with type 2 diabetes have a two-fold increased risk of stroke within the first 5 years of diagnosis compared with the general population [Diabetes UK. Diabetes-related complications can include damage to: the large blood vessels (macrovascular/ cardiovascular complications), leading to heart attack, stroke or circulation problems in the lower limbs. the small blood vessels (microvascular complications), causing problems in the eyes, kidneys, feet and nerves Macrovascular Complications Of Diabetes. Total caloric intake also contributes to development of diabetes. Adequate intake of alcohol may reduce the risk of diabetes, but smoking is proven to lead to diabetes. [7,8] Diabetes affect organs in the long run, leading to serious complications. These complications can be classified as microvascular.

How to prevent the microvascular complications of type 2

Lower BP has been shown to be protective for some of the microvascular complications. How is aspirin beneficial to patients with diabetes? Aspirin can prevent acute clot formation (via prevention of platelet aggregation) to help against CVD Long-term complications of diabetes. The most common long-term diabetes-related health problems are: Damage to the large blood vessels of the heart, brain and legs (macrovascular complications) Damage to the small blood vessels, causing problems in the eyes, kidneys, feet and nerves (microvascular complications OBJECTIVE We investigated whether serum magnesium (Mg2+) was prospectively associated with macro- or microvascular complications and mediated by glycemic control (hemoglobin A1c [HbA1c]), in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We analyzed in 4,348 participants the association of serum Mg2+ with macrovascular disease and mortality (acute myocardial infarction [AMI], coronary. Speak to a member of your diabetes team or contact the Diabetes NSW & ACT Helpline on 1300 342 238 and ask to speak to a diabetes educator. Preventing complications. Making healthy lifestyle choices not only supports general good health they also help to minimise diabetes-related complications Discover All-Natural System That Reverse Type 2 Diabetes & Low Blood Sugar Quickly At Home. Best Diabetes Treatment To Help You Get A Better Quality Of Life. Get Free Video Now

to Prevent Microvascular Complications David M. Kendall, MD Chief Scientific and Medical Officer Microvascular Complications in Diabetes: Discussion Outline: Glycemia and Microvascular Compliations • Clinical Trials - A Brief History - Intensive glucose control and microvascular disease risk - A brief reminder of the Serial Position Effec Prevention of Microvascular Complications in Overweight Diabetics With Surgery or Best Medicine (PROMISE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. (RYGB), improves diabetes and some of its. Patients with diabetes should strive to attain an A1C level of <7%, or as close as possible to 6% without significant hypoglycemia. Reducing A1C by 1% decreases the risk of developing microvascular nephropathy and neuropathy complications by 37%. 8 Patients with diabetes must perform self-monitoring blood glucose testing to achieve A1C goals

The National Institute of Diabetes and Digestive and Kidney Disease-funded Chronic Renal to delay progression and to prevent and treat complications, including malnutrition. more intensive glycemic control in younger patients without a history of severe hypoglycemia or comorbidities in whom prevention of microvascular complications is a. High blood glucose levels for several years is the major factor in the development and progression of microvascular complications in IDDM. Reducing mean blood glucose reduces the risk of progression of diabetic microvascular complications substantially. A curve-linear relationship exists between HbA1c levels and progression of diabetic retinopathy

Microvascular and Macrovascular Complications of Diabetes

An increased burden of microvascular complications is independently associated with reduced global longitudinal strain (GLS) in asymptomatic diabetes mellitus (DM) and nonobstructive coronary artery disease, according to a study published in BMC Cardiovascular Disorders.. In this cross-sectional, single-center study, patients aged ≥18 years with a verified diagnosis of DM were examined with. The actual risk of getting microvascular complications like microalbuminuria and retinopathy progression starts at glycated hemoglobin (HbA1c) level of 7%. As per the American Diabetes Association, a new pediatric glycemic control target of HbA1c 20 years as compared to patients <10 years of age

Objective: Data on microvascular complications in children and adolescents with type 1 diabetes mellitus (T1DM) in Sudan are scarce. This study was aimed at determining the prevalence of diabetic. Traditional Chinese medicine (TCM) is an important complementary strategy for treating diabetes mellitus (DM) in China. Traditional Chinese blood circulation activating drugs are intended to guide an overall approach to the prevention and treatment of microvascular complications of DM. The core mechanism is related to the protection of the vascular endothelium and the basement membrane. Here. In addition, diabetic microvascular complications can reduce life expectancy. The strongest risk factors are glycaemic control and diabetes duration; however, other modifiable risk factors such as hypertension, hyperlipidaemia and smoking, and unmodifiable risk factors including age at onset of diabetes and genetic factors may all play a part

None of the intensification trials has shown a benefit either on loss of visual acuity or prevention of blindness, which are the most specific and most feared microvascular complications of type 2 diabetes. 6 In the ACCORD trial, 3, 8 for example, which reported a difference in HbA1c of 1.1% between groups, moderate loss of vision was not. That means, that microvascular complications of diabetes include: Diabetic Retinopathy. Diabetic retinopathy is the most common diabetic eye disease and is one of the leading causes of blindness. It is caused by changes in the blood vessels of the retina. Find out how to spot that you have this, and what you should do to prevent or treat it Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic.

Preventing microvascular complications of diabete

Describe the benefits and limitations of glycemic, blood pressure, and lipid control in preventing or slowing the progression of diabetic microvascular complications. Recognize the value of treatments that target the underlying causes of diabetic neuropathy, diabetic retinopathy (including diabetic macular edema), and diabetic nephropathy When a person has high blood sugars for a long time, complications can happen in both the small (microvascular) and the large (macrovascular) blood vessels of your body. You can prevent these complications. Two recent studies called the Diabetes Control and Complications Trial (DCCT) and the United Kingdom Prospective Diabetes Stud

Diabetic Microvascular Disease Endocrine Societ

Glycemic control achieved using A1C targets of <7% has been shown to reduce microvascular complications of diabetes and, in type 1 diabetes, mortality. If implemented soon after the diagnosis of diabetes this target is associated with long-term reduction in macrovascular disease The major microvascular complications are diabetic retinopathy, nephropathy, and neuropathy. The diabetic foot ulcer shown is the result of longstanding peripheral neuropathy. Diabetic retinopathy is progressive damage to the retina from longstanding diabetes mellitus that, if untreated, will lead to progressive vision loss and blindness Complications of Diabetes: Screening and Prevention Dr Alison Stewart Consultant Physician Victoria Hospital and QEUH Diabetes Staff Education Course Feb 17 Diabetic Complications Microvascular: • Retinopathy • Nephropathy • Neuropathy Macrovascular: • Coronary heart disease (CHD) • Cerebrovascular disease (CVD

Microvascular complications: pathophysiology and

Diabetes is the most frequent cause of blindness and renal failure in the United States, and the microvascular complications of diabetes rise with increasing duration of disease and worsening glycemic control. 8,9 Although improving glycemic control clearly reduces microvascular complications, it is important to recognize that the incidence of. an attempt to facilitate the government and healthcare systems aware of the enormous worth of prevention, early detection and appropriate management of such microvascular complications. Keywords Diabetes complication, microvascular complications, vascular diseases, diabetes mellitus, paediatric diabetes, retinopathy, nephropathy, neuropathy. Microvascular complications affect smaller blood vessels and can lead to damage to the kidneys, eyes, or nerves. Other less well-known complications include bone conditions (such as osteoporosis in type 1 diabetes Convention partitions the complications of diabetes into two main subtypes. First are the diabetes-specific microvascular complications of retinopathy, nephropathy and neuropathy; second are the atherothrombotic macrovascular complications that account for the majority of premature deaths

Diabetes Microvascular Complications 2017-04-20 AHC

As diabetes is a systemic disease, its effects are felt in virtually all parts of the body. Most diabetes-related complications are related to problems in the blood vessels, usually involving changes in blood flow or in the ability of blood to clot. These complications are generally classified into two broad categories: microvascular (involving. Lifestyle intervention or metformin significantly reduced diabetes development over 15 years. There were no overall differences in the aggregate microvascular outcome between treatment groups; however, those who did not develop diabetes had a lower prevalence of microvascular complications than those who did develop diabetes. This result supports the importance of diabetes prevention

Vascular Complications: No Thanks, I'll Pass! - Taking

The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated diabetes prevention, originally demonstrated during the 3-year Diabetes Prevention Program (DPP), and whether diabetes-associated microvascular complications are reduced. Methods—The DPP (1996-2001) was a randomized trial comparing an intensive lifestyl Type 2 diabetes mellitus is a growing pandemic and a leading cause of morbidity and mortality. 1 After the DCCT (Diabetes Control and Complications Trial) 2 found that tight glycemic control-a glycohemoglobin A1c (HbA1c) <7% (53 mmol/mol)-could prevent or slow the progression of nephropathy, retinopathy, and neuropathy in patients with type 1 diabetes mellitus, a consensus, extended to. prevention of diabetes complications. Learning Objectives: Develop individualized glucose goals for different types of patient scenarios. Compare and contrast self-monitoring of blood glucose to continuous glucose monitors. Design a glucose monitoring plan for a given patient scenario. Describe the microvascular and macrovascula Prevention of Complications of Diabetes. Most of the complications of diabetes can be prevented through good blood glucose control in the early stages of diabetes. If complications have already occurred, further harm can be prevented through: Glucose control - Improved control of blood glucose can reduce the risk of microvascular.

Prevention and treatment of microvascular disease in

The complications of diabetes are indeed serious -- but they are not inevitable, Ziemer tells WebMD. Keeping blood sugar under control is the single the most important factor in preventing them VA/DoD guidelines pocketcard. See Figure 3 for Cates' plot on preventing microvascular complications; Glycemic control and vascular complications in type 2 diabetes by McCulloch DK et al. UpToDate.com accessed May 8, 2018. Ten year follow up VADT by Hayward et al NEJM 2015. Study finding 26% of older patients had tight control with high risk.

The Role of Protein Kinase C in Diabetic Microvascular Damage

Prevention and Management of Diabetes Complications

Microvascular complications. blindness - diabetic retinopathy is the leading cause of preventable sight loss among people of working age in England and Wales A Diabetes Prevention Week. Effect of cilostazol in treating diabetes-associated microvascular complications Nicole J. Asal1 Karolina A. Wojciak 1 Abstract Purpose Cilostazol (Pletal), a phosphodiesterase-3 inhi- bitor, was approved in the United States in 1999 to reduce symptoms of intermittent claudication

Managing and Preventing Complications of Diabete

Over the years, both type 1 and type 2 diabetes mellitus (T2DM) are accompanied by micro-vascular and macro-vascular complications. Although glucose control remains top priority, long term complications have major contribution to the mortality and morbidity. The prevention of complications has been the objectives of research over the years The aim of blood glucose lowering is to reduce the long-term complications of diabetes. Good glycaemic management results in substantial and lasting reductions in the onset and progression of microvascular complications. 1 The impact of glucose control on macrovascular complications is less certain, but numerous studies have confirmed the benefits of controlling modifiable risk factors for. Prevention of Microvascular Complications in Diabetes: Where Do We Stand? 2001/viewarticle/949568 Fasting Glucose Variation Predicts Microvascular Risk in ACCORD and VADT Journal Articl Microvascular complications develop in many patients with insulin-dependent diabetes mellitus, and the effect of intensified insulin treatment on these complications has not been established